Figure 3.

Pathogenesis of fatty pancreas and diabetes in AdrKO mice. (a) AdrKO mice for assessing the effect of adropin-deficiency. (b) A high number of adipocytes were seen infiltrating the exocrine pancreas of the biopsy from AdrKO mice at the end of 30 weeks on HFD. (c)The fasting glucose was significantly higher in AdrKO mice compared to that in WT mice with 8 weeks on HFD. (d) Adropin levels were inversely associated with insulin (INS) in AdrHET mice (n=22). (e) AdrKO mice exhibit reduced eNOS phosphorylation which was reflected as such by brain (neuronal cells), kidney, and pancreas. Islet size appears to be on the larger side and higher expression in AdrKO mice when compared with WT mice