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. 2017 Aug 24;8(8):e3008. doi: 10.1038/cddis.2017.362

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Adropin-deficiency associated with an increased severity of impaired glucose homeostasis associated with obesity. (a) The body weight of heterozygous carriers of the null adropin allele (HET) and adropin knockout (KO) mice were significantly higher than that of wild-type control (WT). (b) Serum insulin in HET and KO groups were significantly higher than that of WT recorded at the end of 8 weeks on HFD. (c) AdrKO mice exhibited fasting hypertriglyceridemia. GTT showed glucose (60 min) (d,e) and glucose (120 min) (d,f) were significantly higher than that of WT. (g) Almost all of the AdrKO mice developed into diabetes under the high fat induced after 30 weeks