Table 1. Effect of administration of rKlotho on Tac-induced renal injury in mice.

	VH	rKlotho	Tac	Tac+rKlotho
Body weight (g)	31±1	32±1	27±11	25±1
Water intake (ml/day)	2.2±0.14	2.3±0.19	4.5±0.671,2	2.9±0.333
Urine volume (ml/day)	0.3±0.03	0.4±0.02	0.8±0.111,2	0.33±0.103
Scr (mg/dl)	0.15±0.2	0.15±0.2	0.4±0.31,2	0.2±0.23
KIM-1 (%)	10.9±2.0	9.0±3.4	19.9±4.01,2	7.6±3.33

Abbreviations: KIM-1, kidney injury marker-1; rKlotho, recombinant Klotho; Scr, serum creatinine; Tac, tacrolimus; VH, vehicle

The values shown are the mean±S.E. (n=8) ¹P<0.05 versus VH; ²P<0.05 versus rKlotho; ³P<0.05 versus Tac.