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A schematic representation of the redox-sensitive events occurring in the lumen of the endoplasmic reticulum upstream of PERK activation. The oxidoreductase ERp57 blocks oxidation of PDI. Thus, loss of functional ERp57 results in PDI oxidation that is in turn necessary for the activation of PERK. Operation of the switch by which active PERK either leads to survival or to apoptosis is not understood so far
