Figure 1.

Expression of mutant p53 promotes cell morphological changes and cell migration. (a–d) H1299 cells stably expressing vector control (V) or a mutant p53 allele (p53-R175H, p53-R248W or p53-R273H) were subjected to western blot analyses using p53 (DO-1) antibody (a); subjected to photograph under a phase-contrast microscope (b); subjected to wound-healing assay (c); or subjected to transwell assays (d). Scale bar =100 μm. ** indicated P<0.01. Results are presented as means and S.E. from three independent experiments in triplicates