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. 2017 Aug 24;8(8):e3016. doi: 10.1038/cddis.2017.384

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effect on ER stress sensors in SMMC-7721 cells. (a) Total proteins were extracted from SMMC-7721 cells treated with the title compound for 0, 3, 6, 12, 24, 36, and 48 h, and were subjected to western blot and densitometric analyses. The densitometric quantitation ratio of ER stress sensors (p-PERK/PERK, p-eIF2α/eIF2α, ATF4, and CHOP) normalized to the β-actin level. (b) The effects of the title compound on IRE1/p-IRE1α, Bcl-2/Bax, and caspase-3 by western blot and densitometric analyses. For the statistics of each panel in this figure, data are expressed as mean±S.D. (n=3); *P<0.05 versus control, **P<0.01 versus control, ***P<0.001 versus control