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. 2017 Aug 10;8(8):e2989. doi: 10.1038/cddis.2017.391

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Dioscin promoted the interaction of c-ABL and ERβ, and directly targeted with ERβ. (a) Effects of dioscin on the interaction of c-ABL and ERβ in PC3 cells. (b) The hydrogen bonding model of dioscin and ERβ. (c) Effect of dioscin on ERβ expression level in PC3 cells after transfecting with mutational-ERβ cDNA. (d) Effect of dioscin on the cell viability of PC3 cells after transfecting with mutational-ERβ cDNA. Data are presented as the mean±S.D. (n=5). *P<0.05 and **P<0.01 versus Vehicle group; ^##P<0.01, Mutant type (MT) versus wild-type (WT) group