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. 2017 Aug 24;8(8):e3009. doi: 10.1038/cddis.2017.405

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effect of CHAC2 on apoptosis and production of T-GSH, GSH, Ca²⁺, and ROS of cancer cells. (a) Representative results of annexin V-FITC/PI staining and quantitative analysis in CHAC2 overexpression or knockdown cells. Values are mean±s.d of three independent experiments. Asterisk indicates statistically significant difference (**P<0.01, *P<0.05). (b) The T-GSH (GSSG+GSH) and GSH concentration of CHAC2-transfected cells comparing with that of controls. (c) Effect of CHAC2 on cytoplasmic Ca²⁺ concentration of cancer cells. (d) Analysis of ROS production in CHAC2-transfected cells. All the above experiments were performed in triplicate, using vector-transfected cells as control. The data were presented as mean±s.d. Asterisk indicates statistically significant difference (**P<0.01, *P<0.05)