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. 2017 Aug 24;8(8):e3009. doi: 10.1038/cddis.2017.405

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of CHAC2 on the cancer cell apoptosis, autophagy and their related proteins. (a) Expression of several key UPR regulators and cell apoptotic regulators examined by western blot in CHAC2 overexpression or knockdown cells. (b) Expression levels of apoptosis factor cyto c and Smac in mitochondria and cytoplasmic of cancer cells were evaluated in CHAC2-transfected cells, using vector transfected cells as control. (c) Determination of the expression of key autophagic regulators by western blot. 5-FU, 5-fluorouracil; c-PARP, cleaved PARP; cyto c, cytochrome c. All the relative quantitive values were put below the correspondent blots