Fig. 7.

Effects of DTX on autophagy in PASMCs. (A and B) Human PASMCs were treated with dimethylsulfoxide (DMSO; 0.1%) or DTX (50 nM) for 22 hours, and cell lysates were subjected to Western blotting to monitor LC3B-II and p62 levels (n = 5–7). (C) Rats were treated with SU5416/hypoxia and injected with saline or DTX. Protein levels of p62 were monitored by Western blotting in isolated PA homogenates (n = 7). *Significant difference between each other at P < 0.05. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.