Table 2.

Association of K2p gene expression and triple negative subtype

	Age/race adjusteda				Mutually adjustedb				Fully adjustedc
	RR	95% CI		p-valued	RR	95% CI		p-valuee	RR	95% CI		p-valuee
KCNK1	1.02	0.94	1.10	6.50E−01	…	…	…	…	…	…	…	…
KCNK2	0.88	0.63	1.22	4.28E−01	…	…	…	…	…	…	…	…
KCNK3	0.95	0.74	1.24	7.25E−01	…	…	…	…	…	…	…	…
KCNK4	1.02	0.94	1.10	6.66E−01	…	…	…	…	…	…	…	…
KCNK5	1.03	1.02	1.04	2.92E−09	2.51	1.88	3.36	4.26E−10	2.22	1.67	2.96	3.81E−08
KCNK6	0.24	0.17	0.33	1.38E−17	0.87	0.76	0.99	2.96E−02	0.88	0.77	1.01	7.68E−02
KCNK7	0.97	0.90	1.05	5.09E−01	…	…	…	…	…	…	…	…
KCNK9	1.02	1.01	1.03	1.43E−03	1.18	1.08	1.30	2.91E−04	1.16	1.06	1.28	2.39E−03
KCNK10	1.06	1.00	1.13	4.44E−02	…	…	…	…	…	…	…	…
KCNK12	1.03	1.02	1.04	8.93E−09	1.54	1.36	1.74	4.60E−12	1.54	1.35	1.76	1.74E−10
KCNK13	0.90	0.74	1.08	2.57E−01	…	…	…	…	…	…	…	…
KCNK15	0.0036	0.00	0.01	2.21E−19	0.28	0.20	0.38	4.44E−16	0.27	0.19	0.38	2.86E−14
KCNK16	0.0199	0.00	5.31	1.69E−01	…	…	…	…	…	…	…	…
KCNK17	1.03	0.91	1.16	6.32E−01	…	…	…	…	…	…	…	…
KCNK18	1.03	0.96	1.10	4.55E−01	…	…	…	…	…	…	…	…

mRNA Expression z-Scores (RNA Seq V2 RSEM)

Reference group for triple negative subtype is luminal A

K2p 2-Pore domain potassium channel, ellipses not applicable

^aModels adjusted for race and age, and K2p gene expression is modeled as individual continuous covariates (n = 482)

^bModels adjusted for race, age and other selected K2p gene expression variables as continuous covariates, while main K2p gene of interest is modeled as categorical tertiles (n = 482); only significant K2p gene expression from univariate glm included

^cFully adjusted model adds stage as an ordinal variable and menopausal status as a binary variable to the mutually adjusted mode; only significant K2p gene expression from univariate glm included

^dFrom logistic regression models (glm), Bonferroni adjusted significance threshold = p < 0.0033 (significant values are in italics)

^eFrom glm models p-trend, Bonferroni adjusted significance threshold = p < 0.0033