Table 1.
Cytotoxicity data for several Leucetta-derived alkaloids and analogs in MCF7 cells using an MTT growth assay.
| Entry | Compound | IC50/μMol | Entry | Compound | IC50/μMol |
|---|---|---|---|---|---|
| 1 |
 17 |
>100 | 13 |
 Kealiinine A (59) |
23.4±1.9 |
| 2 |
 Preclathridine A (19) |
>100 | 14 |
 60 |
28.0±1.3 |
| 3 |
 Clathridine A (1) |
5.78±0.04 | 15 |
 Kealiinine B (61) |
28.8±1.2 |
| 4 |
 Isonaamine C (28) |
>100 | 16 |
 62 |
99.8±0.9 |
| 5 |
 Isonaamidine E (2) |
4.4±0.2 | 17 |
 Kealiinine C (63) |
>100 |
| 6 |
 36 |
19.5±1.5 | 18 |
 64 |
68.2±1.6 |
| 7 |
 Naamidine G (4) |
5.08±0.05 | 19 |
 Isokealiinine C (65) |
22.7±1.0 |
| 8 |
 39 |
16.3±0.4 | 20 |
 2-Deamino-2-oxokealiinine C (66) |
29.9±0.3 |
| 9 |
 Naamine G (56) |
76.9±0.97 | 21 |
 2-Deoxykealiiquinone (67) |
41.1±0.1 |
| 10 |
 Naamidine H (5) |
4.94±0.12 | 22 |
 Kealiiquinone (6) |
91.9±0.5 |
| 11 |
 57 |
92.0±2.2 | 23 |
 2-Deoxy-2-aminokealiiquinone (68) |
43.8±0.4 |
| 12 |
 58 |
>100 |