Fig. 2.

Transcription factors differentially-targeting genes in cell lines and their tissues of origin. a Illustration of the TF out-degree difference between each cell line and its tissue of origin. Positive values indicate higher targeting in cell lines, and negative values indicate higher targeting in tissues. b Function of the TFs with the largest difference in out-degree comparing LCL-vs-blood; and fibroblast-vs-skin regulatory networks. The complete table with references and differential expression results is shown in Additional file 8