Table 1.
Summary of EGFR and HER2 exon 20 insertion mutations.
| EGFR | Number (N=44) | Amino acid sequence |
|---|---|---|
| (codon number) | 765 770 775 | |
| (wild type sequence) | EAYVMASVDNPHVCRLL | |
|
| ||
| D770_N771insSVD | 10 | EAYVMASVDSVDNPHVCRLL |
| V769_D770insASV | 6 | EAYVMASVASVDNPHVCRLL |
| H773_V774insH | 4 | EAYVMASVDNPHHVCRLL |
| A763_Y764insFQEA | 3 | EAFQEAYVMASVDNPHVCRLL |
| D770delinsGY | 3 | EAYVMASVGYNPHVCRLL |
| V774_C775insHV | 3 | EAYVMASVDNPHVHVCRLL |
| H773_V774insNPH | 2 | EAYVMASVDNPHNPHVCRLL |
| H773_V774insPH | 2 | EAYVMASVDNPHPHVCRLL |
| Y764_V765insHH | 1 | EAYHHVMASVDNPHVCRLL |
| D770_N771insGL | 1 | EAYVMASVDGLNPHVCRLL |
| D770_N771insSVG | 1 | EAYVMASVDSVGNPHVCRLL |
| D770delinsVG | 1 | EAYVMASVVGNPHVCRLL |
| N771_P772insH | 1 | EAYVMASVDNHPHVCRLL |
| N771_P772insV | 1 | EAYVMASVDNVPHVCRLL |
| N771delinsGY | 1 | EAYVMASVDGYPHVCRLL |
| N771delinsTH | 1 | EAYVMASVDTHPHVCRLL |
| P772_H773insDNP | 1 | EAYVMASVDNPDNPHVCRLL |
| P772_H773insPNP | 1 | EAYVMASVDNPPNPHVCRLL |
| H773_V774insAH | 1 | EAYVMASVDNPHAHVCRLL |
| HER2 | Number (N=48) | Amino acid sequence |
|---|---|---|
| (codon number) | 775 780 785 | |
| (wild type sequence) | EAYVMAGVGSPYVSRLL | |
|
| ||
| A775_G776insYVMA | 33 | EAYVMAYVMAGVGSPYVSRLL |
| G776delinsVC | 5 | EAYVMAVCVGSPYVSRLL |
| P780_Y781insGSP | 5 | EAYVMAGVGSPGSPYVSRLL |
| M774delinsWLV | 1 | EAYVWLVAGVGSPYVSRLL |
| A775_G776insSVMA | 1 | EAYVMASVMAGVGSPYVSRLL |
| A775_G776insI | 1 | EAYVMAIGVGSPYVSRLL |
| G776delinsLC | 1 | EAYVMALCVGSPYVSRLL |
| G778_S779InsCPG | 1 | EAYVMAGVGCPGSPYVSRLL |