Table 2.
Presentation and in-hospital characteristics and discharge interventions of the study population
| Patient characteristics | Normal Weight (n = 5920) | Overweight (n = 7982) | Obese class I (n = 3837) | Obese class II (n = 1192) | Obese class III (n = 568) | P-value |
|---|---|---|---|---|---|---|
| Presentation and in-hospital characteristics | ||||||
| Heart rate, bpm | 74 (62–88) | 74 (63–88) | 75 (63–88) | 77 (65–90) | 78.5 (66–92) | <0.001 |
| Systolic blood pressure, mmHg | 138 (116–158) | 141 (120–162) | 142 (122–163) | 143 (122–164) | 145 (121–164) | <0.001 |
| Signs of HF, number (%) | 453 (7.7) | 641 (8.0) | 309 (8.1) | 106 (8.9) | 49 (8.6) | 0.17 |
| Initial haemoglobin, g/dL | 13.5 (12.3–14.7) | 14.0 (12.8–15.1) | 14.0 (12.9–15.2) | 13.9 (12.7–15.1) | 13.5 (12.5–14.7) | <0.001 |
| Initial creatinine, mg/dL | 1.0 (0.9–1.3) | 1.1 (0.9–1.3) | 1.1 (0.9–1.3) | 1.1 (0.9–1.3) | 1.1 (0.9–1.3) | <0.001 |
| Initial troponin, xULN | 1.2 (0.3–11.9) | 1.0 (0.3–10.8) | 1.0 (0.2–9.8) | 1.0 (0.3–9.9) | 1.4 (0.3–15.2) | 0.005 |
| LVEF, number (%) | <0.001 | |||||
| ≥50% | 2661 (46.8) | 3906 (50.8) | 1908 (51.6) | 563 (49.6) | 303 (55.8) | |
| 25–50% | 2785 (49.0) | 3515 (45.8) | 1665 (45.0) | 546 (48.1) | 225 (41.4) | |
| <25% | 224 (3.9) | 239 (3.1) | 100 (2.7) | 23 (2.0) | 12 (2.2) | |
| Multi-vessel coronary disease, number (%) | 4018 (68.4) | 5479 (69.1) | 2623 (68.8) | 785 (66.4) | 356 (63.1) | 0.10 |
| Overall reperfusion therapy | 5361 (96.2) | 7157 (95.8) | 3440 (95.3) | 1081 (96.4) | 527 (97.4) | 0.41 |
| Primary PCI | 4922 (89.1) | 6527 (88.1) | 3103 (86.7) | 985 (88.9) | 484 (90.1) | 0.03 |
| Door to balloon time (minutes) | 64.0 (49.0–81.0) | 63.0 (48.0–79.0) | 64.0 (48.0–80.0) | 64.0 (50.5–82.0) | 64.0 (48.0–81.5) | 0.72 |
| In-hospital CABG, number (%) | 329 (5.6) | 605 (7.6) | 288 (7.5) | 70 (5.9) | 24 (4.2) | 0.02 |
| In-hospital cardiogenic shock, number (%) | 289 (4.9) | 310 (3.9) | 140 (3.7) | 39 (3.3) | 20 (3.5) | <0.001 |
| In-hospital major bleeding, number (%) | 723 (12.2) | 801 (10.0) | 365 (9.5) | 127 (10.7) | 71 (12.5) | <0.001 |
| Aspirin within 24 h, number (%) | 5788 (98.9) | 7787 (98.9) | 3747 (98.9) | 1160 (98.9) | 553 (99.1) | 0.91 |
| P2Y12 receptor inhibitor within 24 h, number (%) | 5417 (91.5) | 7240 (90.7) | 3457 (90.1) | 1097 (92.0) | 536 (94.4) | 0.65 |
| Statin within 24 h, number (%) | 4154 (72.7) | 5611 (72.9) | 2709 (72.9) | 856 (75.0) | 418 (75.3) | 0.22 |
| Discharge interventions | ||||||
| Aspirin, number (%) | 5747 (98.9) | 7748 (99.0) | 3719 (98.9) | 1157 (99.1) | 545 (98.4) | 0.97 |
| P2Y12 receptor inhibitor, number (%) | 5552 (94.2) | 7365 (92.7) | 3531 (92.4) | 1116 (93.9) | 534 (94.9) | 0.04 |
| Statin, number (%) | 5440 (94.6) | 7349 (94.9) | 3552 (95.0) | 1108 (96.1) | 518 (94.5) | 0.15 |
| Beta blocker, number (%) | 5413 (97.4) | 7408 (97.8) | 3587 (97.5) | 1112 (97.1) | 532 (97.8) | 0.97 |
| ACE inhibitor/ARB, number (%) | 4200 (76.8) | 5823 (78.3) | 2928 (81.1) | 909 (81.3) | 446 (82.9) | <0.001 |
| Aldosterone antagonist, number (%) | 235 (4.1) | 331 (4.2) | 180 (4.8) | 61 (5.2) | 28 (5.1) | 0.02 |
| Cardiac rehabilitation referral, number (%) | 4665 (84.7) | 6440 (85.0) | 3126 (85.3) | 973 (84.6) | 454 (85.3) | 0.58 |
Data represented as median (IQR) or number (%). P-value was calculated by comparing only non-missing row values; all P-values are 5-group comparisons. BMI (kg/m2) categories are according to the World Health Organization classification: normal weight (18.5–24.9), overweight (25–29.9), class I obese (30–34.9), class II obese (35–39.9), and class III obese (≥40).
ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; BPM, beats per minute; CABG, coronary artery bypass graft; LVEF, left ventricular ejection fraction; HF, heart failure; PCI, percutaneous coronary intervention; ULN, upper limit of normal; BMI, body mass index.