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L253X retains minimal ability to transactivate rhodopsin promoter in the presence of NRL. Dual luciferase assays showing a dose-dependent increase in CRX transactivation activity of normal or mutant (CRX1-254) in the presence of constant amount of NRL (mean ± SEM, n = 3; **** P < 0.0001; 2-way ANOVA with Bonferroni's multiple comparisons test).
