Skip to main content
. 2017 Sep 5;23:4284–4290. doi: 10.12659/MSM.902936

Figure 5.

Figure 5

Knockdown of miR-122 promoted cell proliferation by regulating the PTEN/PI3K/AKT pathway. To investigate the effect of miR-122 on the PTEN/PI3K/AKT pathway, the protein levels of PI3K, AKT, and PTEN were analyzed by Western blotting. Hypoxia significantly inhibited the PTEN/PI3K/AKT pathway, overexpression of miR-122 further inhibited the PTEN/PI3K/AKT pathway, and knockdown of miR-122 significantly activated the PTEN/PI3K/AKT pathway. Scramble and ASO-NC were the controls of miR-122 and ASO-miR-122, respectively. * P<0.05; ** P<0.01; *** P<0.001.