Table 2. Non-synonymous polymorphisms present in tooth proteins of Neanderthal and Denisova hominins.
| Gorilla | Chimp | Modern humans | Neanderthals | Denisova | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variants identified in archaic hominins | (global worldwide frequency) | Altaï (Russia) | Vindija (Croatia) | Mezmaiskaya (Russia) | El Sidron (Spain) | ||||||
| Vi33.15 | Vi33.16 | Vi33.25 | Vi33.26 | Mez1 | |||||||
| Ameloblastin (AMBN) | |||||||||||
| G78S (rs143795139) derived | G | G | S (0.0001) | G | S | G | G | G | G | G | |
| M273V (rs564905233) derived | M | M | V (0.001) | M | M | M | V | ||||
| Amelotin (AMTN) | |||||||||||
| R171H (rs117133443) derived | R | R | H (0.0001) | R | R | R | R | H | |||
| A200V (rs376682442) derived | T | A | V (0.005) | A | A | A | A | V | |||
| Cementum protein 1 (CEMP1) | |||||||||||
| R15Q (rs370735504) derived | R | Q (0.0001) | R | R | Q | ||||||
| K55E (rs13331643) ancestral | E | E (0.07) | E | ||||||||
| R80H (rs79379654) derived | R | H (0.001) | R | H | |||||||
| Dentin matrix acidic phosphoprotein 1 (DMP1) | |||||||||||
| R173Q (rs747698893) derived | R | R | Q (0.0001) | R | R | R | Q | ||||
| N483T (rs574215585) derived | N | N | T (0.005) | T | T | T | N | ||||
| Enamelin (ENAM) | |||||||||||
| G389S (rs74511578) derived | G | G | S (0.01) | S | S | S | S | G | |||
| T415I (rs779308123) derived | T | T | I (0.0001) | T | T | T | T | I | T | T | |
| R429H (rs375758699) derived | R | R | H (0.0005) | R | R | R | H | ||||
| T648I (rs7671281) derived | T | T | I (0.82) | I | I | I | |||||
| T951M (rs561402393) derived | T | T | M (0.0001) | T | M | M | M | T | T | ||
| Matrix Gla protein (MGP) | |||||||||||
| A8V (rs142330429) derived | A | A | V (0.01) | V | V | V | V | V | V | ||
| T127A (rs4236) ancestral | A | A (0.39) | A | A | A | A | A | A | |||
Bold characters indicate the aminoacid and position corresponding to the archaic hominin variant. Empty cell indicates no sequence read available at this position. Yellow: common to archaic hominins; Dark green: specific to Neanderthals; Light green: specific to the Vindija cave; Dark blue: specific to Denisova; Light blue: at least present in Denisova.