Table 2.
Mean pharmacokinetics (PK) of Posaconazole (PCZ) after a single oral (PO) dose of 400 mg susp and 400 mg twice daily in healthy volunteers at steady state [2].
| Single Dose | Steady State | |
|---|---|---|
| Parameter | Value | Value |
| Maximum concentration (ng/mL) | 555 | |
| Average concentration (ng/mL) | 723 | |
| Time to reach maximum concentration (hours) | 5.5 * | 5 * |
| Serum protein binding (%) | 98.5 | |
| Volume of distribution (Liters) | 3088 | |
| AUC0–X (ng⋅h/mL) | 11295 a | 9093 b |
| Systemic clearance (L/hr) | 43 | 76.1 |
| Half-life (h) | 24.1 | 31.7 |
| Urinary excretion (%) | 14 | |
| Dialyzable | No | |
| Food or nutritional supplement enhance GI absorption | Yes |
* Data is presented as median; PK = pharmacokinetics; PCZ = posaconazole; PO = oral; susp = suspension; mg = milligram; AUC = area under the concentration time curve from time zero to time X; a = 0 to infinity; b = 0 to 12 h.