Table 3. Measurement results of DKK1, TEMs or AFP alone and their combinations for HCC diagnosis in different cohorts.
| Markers | AUC(95% CI) | Sn(%) | Sp(%) | Sn+Sp | PPV(%) | NPV(%) |
|---|---|---|---|---|---|---|
| HCC vs LC,CHB and NC | ||||||
| DKK1 | 0.728(0.654–0.793) | 89.02 | 52.27 | 1.41 | 63.48 | 83.64 |
| TEMs | 0.701(0.626–0.768) | 71.95 | 70.45 | 1.42 | 69.41 | 72.94 |
| AFP | 0.712(0.638–0.779) | 45.12 | 85.23 | 1.30 | 74.00 | 62.50 |
| DKK1+TEMs+AFP | 0.833(0.768–0.886) | 76.83 | 77.27 | 1.54 | 75.90 | 78.16 |
| HCC vs LC and CHB | ||||||
| DKK1 | 0.673(0.588–0.752) | 89.02 | 43.86 | 1.33 | 69.52 | 73.53 |
| TEMs | 0.673(0.589–0.750) | 71.95 | 68.40 | 1.40 | 76.62 | 62.90 |
| AFP | 0.664(0.579–0.742) | 45.12 | 77.19 | 1.22 | 74.00 | 49.44 |
| DKK1+TEMs+AFP | 0.789(0.711–0.853) | 76.83 | 68.42 | 1.45 | 77.78 | 67.24 |
| HCC vs LC | ||||||
| DKK1 | 0.664(0.548–0.733) | 89.02 | 37.93 | 1.27 | 80.22 | 55.00 |
| TEMs | 0.657(0.561–0.745) | 71.95 | 65.52 | 1.37 | 85.51 | 45.24 |
| AFP | 0.592(0.495–0.685) | 45.12 | 65.52 | 1.11 | 78.72 | 29.69 |
| DKK1+TEMs+AFP | 0.762(0.672–0.838) | 76.83 | 62.07 | 1.39 | 85.14 | 48.65 |
| AFP-negative HCC vs LC,CHB and NC | ||||||
| DKK1 | 0.709(0.624–0.795) | 91.11 | 52.27 | 1.43 | 49.40 | 92.00 |
| TEMs | 0.739(0.648–0.829) | 80.00 | 70.45 | 1.50 | 58.06 | 87.32 |
| DKK1+TEMs | 0.785(0.709–0.861) | 40.00 | 82.95 | 1.23 | 54.55 | 73.00 |
| AFP-negative HCC vs LC and CHB | ||||||
| DKK1 | 0.649(0.542–0.755) | 91.11 | 43.86 | 1.35 | 56.16 | 86.21 |
| TEMs | 0.708(0.605–0.812) | 80.00 | 68.42 | 1.48 | 66.67 | 81.25 |
| DKK1+TEMs | 0.729(0.632–0.827) | 40.00 | 77.19 | 1.57 | 58.06 | 61.97 |
| AFP-negative HCC vs LC | ||||||
| DKK1 | 0.620(0.483–0.757) | 91.11 | 37.93 | 1.29 | 69.49 | 73.33 |
| TEMs | 0.692(0.564–0.819) | 80.00 | 65.52 | 1.46 | 78.26 | 67.86 |
| DKK1+TEMs | 0.707(0.577–0.837) | 40.00 | 72.41 | 1.12 | 69.23 | 43.75 |