Table 2. Data abstraction form to assess the quality and transparency in reporting.

	Ratings
	2	1	0
Description of Animals:
Source	Yes, all reported	Yes, some reported	No, not reported
Species	Yes, all reported	Yes, some reported	No, not reported
Strain	Yes, all reported	Yes, some reported	No, not reported
Sex	Yes, all reported	Yes, some reported	No, not reported
Age	Yes, all reported	Yes, some reported	No, not reported
Inbred and strain characteristics of genetically modified animals detailed?	Yes, all reported	Yes, some reported	No, not reported
	N/A (genetically modified animals not used)
Identification of committee approving the animal experiments?		Yes	No
Statistics:
Define statistical test used for each relevant figure presented?	Yes, all reported	Yes, some reported	No, not reported
Define test as one-sided or two-sided?	Yes, all reported	Yes, some reported	No, not reported
Exact value of N for each relevant figure presented?	Yes, all reported	Yes, some reported	No, not reported
Definition of center, dispersion and precision measures in figures (e.g., mean, median, SD, SEM, confidence intervals)?	Yes, all reported	Yes, some reported	No, not reported
Replicates: Do investigators report how many times experiments were performed independently?	Yes, all reported	Yes, some reported	No, not reported
Replicates: Do investigators distinguish biological independent data points and technical replicates?	Yes, all reported	Yes, some reported	No, not reported
Randomization: Do authors include a statement whether the samples were randomized even if no randomization was used?	Yes, reported and performed	Yes, reported but not performed	No, not reported
Blinding: Do authors include a statement whether experimenters were blinded even if no blinding occurred?	Yes, reported and performed	Yes, reported but not performed	No, not reported
Sample size estimation: Do authors include a statement of sample size estimation?	Yes, reported and performed	Yes, reported but not performed	No, not reported