Table 1.
Summary of 13C-MFA software.
| Name | Capabilities | Labeled Pattern | Key Solver (Algorithm) | Platform | Developer |
|---|---|---|---|---|---|
| 13CFLUX2 [66] | Steady-state 13C-MFA | EMU [67] d | IPOPT | UNIX/Linux | Wiechert’s group |
| Metran [67] | Steady-state 13C-MFA | EMU | fmincon | MATLAB | Antoniewicz’s group |
| FIA [177] | Steady-state 13C-MFA | Fluxomer | SNOPT [178] | UNIX/Linux | Young’s group |
| influx_s [179] | Steady-state 13C-MFA | Cumomer | NLSIC [179] | UNIX/Linux | Portais’s group |
| C13 [180] | Steady-state 13C-MFA | SFL [181] e | fmincon | MATLAB | Nielsen’s group |
| OpenFLUX2 [65] | Steady-state 13C-MFA with PLEs a | EMU | fmincon | MATLAB | Mashko’s group |
| FiatFLUX [69] | METAFoRA b, steady-state 13C-MFA | MDV f | fmincon | MATLAB | Sauer’s group |
| INCA [68] | Steady-state 13C-MFA and INST-13C-MFA c | EMU | Customized Differential Equation Solver [71] | MATLAB | Young’s group |
| OpenMebius [182] | Steady-state 13C-MFA and INST-13C-MFA c | EMU | Levenberg-Marquardt method [183] | MATLAB | Shimizu’s group |
a PLEs: Parallel isotopic experiments; b METAFoRA: Metabolic flux ratio analysis; c INST-13C-MFA: isotopic nonstationary 13C-metabolic flux analysis; d EMU: elementary metabolite unit; e SFL: summed fractional labeling; f MDV: mass distribution vectors.