Table 5. Influencial factors for the presence of severe fatigue (Grade 1+2) at 12 months.

	Univariate			Multivariate
Variables	OR	95%CI	p value	OR	95%CI	p value
Age	1.029	1.007 to 1.053	<0.01	1.014	0.985 to 1.045	0.35
Male gender	0.91	0.55 to 1.50	0.71	1.14	0.57 to 2.31	0.71
Dialysis vintage	1.001	0.998 to 1.004	0.37	1.005	1.001 to 1.010	0.02
DM	1.53	0.92 to 2.56	0.10	1.61	0.82 to 3.21	0.17
Past history of CVD	1.07	0.63 to 1.81	0.81	0.96	0.46 to 1.99	0.92
Dry weight at baseline	0.99	0.97 to 1.01	0.38
Predialysis SBP at baseline	0.997	0.987 to 1.007	0.59
Predialysis DBP at baseline	0.991	0.974 to 1.009	0.33
Hemoglobin at baseline	0.933	0.755 to 1.151	0.52
BUN at baseline	0.987	0.970 to 1.003	0.11
Cr at baseline	0.942	0.860 to 1.031	0.19
Serum albumin at baseline	0.191	0.076 to 0.455	<0.01	0.566	0.173 to 1.813	0.34
Ferritin at baseline	1.0001	0.9978 to 1.0022	0.94
CRP at baseline	1.669	1.115 to 2.687	0.01	1.665	1.076 to 2.689	0.02
B2M at baseline	1.043	1.006 to 1.084	0.02	0.995	0.948 to 1.044	0.84
Fatigue day on HD at baseline	8.45	4.74 to 15.53	<0.01	10.03	5.02 to 21.12	<0.01
E-HD	0.54	0.33 to 0.89	0.02	0.30	0.14 to 0.61	<0.01

DM, diabetes mellitus; CVD, cardiovascular disease; SBP, systolic blood pressure, DBP, diastolic blood pressure; BUN, blood urea nitrogen; Cr, serum creatinine; CRP, C-reactive protein; B2m, B2-microglobulin; E-HD, electrolyzed water hemodialysis.

In multivariate analysis, in addition to factors with p-value less than 0.1 by univariate analysis, clinical-relevant possible influential factors for the fatigue were employed for analysis. Those include patients’ basal characteristics, such as, gender, dialysis vintage, and history of CVD.