Table 1. General characteristics of the studies.

Author and year of publication	Study region	Study period	Design of study	TB annual incidence rate per 100 000 inhabitants	Study duration (months)	Number of genotyped subjects	Sampling fraction (%)	DM diagnosis based on:	Primary genotyping method	Secondary genotyping method	Application of secondary genotyping method	Cluster definition	Index case of the cluster	Subjects in the cluster (%)	Contact tracing
Hernández-Garduño et al., 2002 [55].	Greater Vancouver, British Columbia, Canada	1995–1999	Cohort	6.0**	50	793	100	Information obtained from the dataset of the TB division.	RFLP-IS6110	Spoligotyping	< 6 copies of IS6110	≥ 2 strains with identical DNA (≥ 6 copies with RFLP, or < 6 copies with s poligotyping	First diagnosed patient	17.3	Yes
Borrell et al., 2010 [21].*	Barcelona, Spain	2003–2004	Cohort	21.6	24	115	67.4	Information obtained from TB program dataset of Barcelona and microbiology areas of hospitals and clinical centers.	RFLP-IS6110	MIRU-12 loci	< 6 copies of IS6110 or ≥6 bands with a different one	≥ 2 patients: (i) RFLP-IS6110 ≥ 6 bands in the same position; (ii) RFLP-IS6110 < 6 bands in the same position but with identical MIRU-12 loci; (iii) RFLP-IS6110 ≥ 6 bands that differ in 1 band but with identical MIRU-12 loci	Subject with earliest onset of pulmonary symptoms or the one that started treatment first (asymptomatic)	32	Unknown
Jiménez-Corona et al., 2013 [56].	Orizaba, Veracruz, México	1995–2010	Cohort	21**	181	1013	80	Previous diagnosis from a physician or oral hypoglycemic medication or insulin administration or treatment	RFLP-IS6110	Spoligotyping	< 6 copies of IS6110	≥ 2 two or more isolates from different patients identified within 12 months of each other and with six or more IS6110 bands in an identical pattern, or < 6 bands with identical IS6110 RFLP patterns and a spoligotype with the same spacer oligonucleotides	Not specified	28.8	Unknown
Wang et al., 2014 [57].	Beijing, China	2009–2011	Cohort	73**	48	115	100	Clinical data obtained from the patient`s medical history	MIRU-VNTR 24 loci (up to 28)	Does not apply	Does not apply	≥ 2 strains showing identical patterns MIRU-VNTR	Not specified	17.4	Unknown
González et al., 2015 [54].	La Habana, Cuba	2009	Cohort	8.2	12	59	61	Clinical information obtained from the national statistics / epidemiology data base of the public health ministry of Cuba	MIRU-VNTR 24 loci	Does not apply	Does not apply	Strains with identical genetic pattern	Not specified	54.2	Yes
Yang et al., 2015 [58].	China	2009–2012	Cohort	73**	36	1948	82	Clinical information obtained by professional interviewers with standardized questionnaire.	MIRU-VNTR 29 loci	Does not apply	Does not apply	Strains with identical genetic pattern	First patient in the cluster	31	Yes

*We used only information from foreign patients;

** Annual rates were taken from World Bank [18]