Table 3. IPA-identified canonical pathways of genes involved in signaling of selected pituitary-derived hormones differentially-expressed by pituitary tissue of steers grazing high (HE) vs. low (LE) endophyte-infected forages.
| Canonical Pathway | Number1 | Gene Symbol | Ratio2 | -log (P-value) |
|---|---|---|---|---|
| Melanocyte Development and Pigmentation Signaling |
7 | PIK3R1,FGFR1,CREB3,POMC,RPS6KA5,ADCY8,PRKAR1A | 0.07 | 2.38 |
| Corticotropin-releasing Hormone Signaling |
7 | PRKCQ,BDNF,CREB3,POMC,ADCY8,PRKCA,PRKAR1A | 0.06 | 1.87 |
| Growth Hormone Signaling | 6 | IGF2,PRKCQ,PIK3R1,FGFR1,RPS6KA5,PRKCA | 0.07 | 2.06 |
| GnRH Signaling | 10 | MAP2K6,PRKCQ,PAK6,CREB3,MAPK10,MAP3K5,ADCY8,MAP3K3,PRKCA,PRKAR1A | 0.07 | 3.26 |
1The number of genes (listed in the “Symbol” column) associated with the particular canonical pathway.
2The ratio is calculated as the number of genes in a given pathway that meet cutoff criteria (e.g., the ANOVA P-value for the differential expression between HE and LE groups is less than 0.001) divided by the total number of genes that make up that pathway.