Skip to main content
. 2017 Aug 31;13(8):e1006587. doi: 10.1371/journal.ppat.1006587

Fig 10. A proposed model for Rep mediated recruitment of histone monoubiquitination machineries on viral promoter and stimulation of geminivirus transcription.

Fig 10

In the geminivirus-infected cells, Rep protein redirects NbUBC2 into the nucleus. NbUBC2 in association with NbHUB1 form monoubiquitination machinery in the nucleus. Rep associated with the nucleosomes of viral genome recruits monoubiquitination machinery to ubiquitinate NbH2B on the viral promoter and eventually promotes the trimethylation of H3-K4. Thus Rep-mediated recruitment of the monoubiquitination apparatus stimulates the bi-directional transcription of the viral genome.