Fig 12. Spatio-temporal SR Ca²⁺ dynamics during Ca²⁺ transient alternans.

A) Whole cell nSR Ca²⁺ concentration associated with four cycles during Ca²⁺ transient alternans (the same four cycles as in Fig 11). B) Snapshots of spatial Ca²⁺ distribution in the nSR associated with two beats (large and small amplitude, i-iii and iv-vi, respectively). Timings of snapshots for both beats are identical relative to the applied stimulus: i,iv - 15ms, ii,v 0–25ms, and iii,vi - 50ms.