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. 2017 Aug 31;13(8):e1006598. doi: 10.1371/journal.ppat.1006598

Fig 7. Virion-associated Vpr does not affect the activation of NF-κB in infected T cells.

Fig 7

(A-D) SupD1 cells were transduced with the indicated VSV-G pseudotyped CH293.1 constructs. (A) HIV-1 CH293, (B) SIVwrc, (C) SIVolc, or (D) SIVgsn Vpr were either delivered in cis (i.e. incorporated in viral particles AND encoded in the viral genome) or in trans (i.e. incorporated in viral particles, but not encoded in the viral genome). CH293.1 wild type and CH293.1 vpu- vpr- served as controls. Cells were harvested at the indicated time points post-transduction to determine the activation levels of NF-κB. The mean values of triplicate infections ± SD are shown. Asterisks indicate a statistically significant difference compared to the mock control (*p<0.05; **p < 0.01; ***p < 0.001).