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. 2017 Jan 27;8(4):383–391. doi: 10.1080/19491034.2017.1280209

Figure 2.

Figure 2.

Differences in structure and function across chromosomes. The gene expression (top bar plot,1Mb resolution), Fiedler vector (middle bar plot, 1 Mb resolution), and a portion of the Hi-C matrix with TAD boundaries overlaid (heat map, 100 kb resolution) for chromosome 18 in (A) 2D culture, (B) 3D culture, and (C) the difference between the cultures. (D) Strong interactions within the portion of chromosome 18 shown in A-C in the 2D sample (red), 3D sample (yellow), and both samples (blue). The gene expression (1Mb resolution), Fiedler vector (1 Mb resolution), and a portion of the Hi-C matrix with TAD boundaries overlaid (100 kb resolution) for chromosome 19 in (E) for 2D culture (F) 3D culture, and (G) the difference between cultures. (H) Strong interactions within the portion of chromosome 19 shown in E-G in the 2D sample (red), 3D sample (yellow), and both samples (blue).