Figure 6.

Model for post-mitotic nuclear import of PML. PML within a single MAPP is depicted as yellow spheres. KPNB1 (purple) and FG-NUPs (green) are recruited successively during G1 phase to form a CyPN. The CyPN dissociates into smaller components (illustrated by smaller spheres) that can translocate through a nuclear pore. We propose that these smaller nuclear cargo complexes may retain an outer layer of FG-repeat proteins that have the potential to facilitate interactions with the nuclear pore environment (gray ovals = scaffold NUPs; green area = hydrogel-like web of FG-repeats). On the nucleoplasmic side, PML and KPNB1 dissociate.