Figure 1.

Normal diffusion (blue) of a particle driven by thermal noise characterized by the MSD, which is proportional to both the diffusion coefficient $D$ and time $t$. Meanwhile, the diffusive movement of a monomer within a polymer globule represents the subdiffusion $\text{MSD}\left(t\right)=D_{\text{sub}}{t}^{\beta }$ due to the structural restriction of the globule. A larger globule results in higher mobility of a monomer (orange, upper). As is shown in Eq. (2), as a polymer globule becomes smaller and more compact, the MSD also becomes smaller (green, lower).