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. 2017 Sep 13;3(9):e1603259. doi: 10.1126/sciadv.1603259

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Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1 — Plasma levels of cFGF23 (black filled bars) and iFGF23 (gray filled bars) were measured in WT, untreated, and TM5441-treated Pai-1stab mice (A) and in WT, kl/kl, TM5441-treated kl/kl, and kl/klpai-1^−/− mice (B). As seen in (A), changes in cFGF23 levels due to PAI-1 overexpression and TM5441 treatment were both significant in Pai-1stab mice. Similarly, TM5441 treatment and PAI-1 deficiency significantly reduced cFGF23 and iFGF23 levels in kl/kl mice. ^#P = 0.0003, ^$P = 0.0001 versus kl/kl cFGF23; *P = 0.03, **P = 0.001 versus kl/kl iFGF23. Analysis of the measurements by one-way analysis of variance (ANOVA) yielded significant differences (P < 0.0001) for both Pai-1stab and kl/kl mice groups.