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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Cardiovasc Ther. 2017 Jun;35(3):10.1111/1755-5922.12259. doi: 10.1111/1755-5922.12259

Figure 2.

Figure 2

Treatment with sEH inhibitors decreases IR-induced increase in resting tension. (A) Treatment with vehicle did not change resting tension after IR injury, whereas treatment of sEH inhibitors reduced significant (*** p < 0.001) increase in resting tension in comparison to normal control rats treated with water. (B) Hypertension did not further increase resting tension significantly after IR, but treatment with lisinopril and sEH inhibitors could significantly reduce (*** p < 0.001) hypertension driven increase in resting tension in comparison to untreated hypertensive rats. Lisinopril (15 mg/kg) was more effective (p < 0.05) than TPPU (0.1 mg/kg). (C) Diabetes did not further affect resting tension after IR in comparison to normal rats treated with water, but treatment with metformin and sEH inhibitors significantly reduced (*** p < 0.001) increase in resting tension in comparison to untreated diabetic rats. Metformin (500 mg/kg) was more effective (*** p < 0.001) than sEH inhibitors. Data are presented as mean ± SEM of 6 observations. One-way ANOVA followed by Tukey’s multiple comparison test was used for statistical calculation.