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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Cardiovasc Ther. 2017 Jun;35(3):10.1111/1755-5922.12259. doi: 10.1111/1755-5922.12259

Figure 3.

Figure 3

Treatment with sEH inhibitors reduces IR-induced decrease in the developed tension. (A) Treatment with vehicle did not change the tension developed after IR injury, whereas treatment with sEH inhibitors reduced the significant decrease (* p < 0.05) in developed tension in comparison to normal control rats treated with water. (B) Hypertension decreased developed tension significantly (a p < 0.05) after IR in comparison to normotensive, and treatment with lisinopril significantly reduced (*** p < 0.001) hypertension driven decrease in the developed tension in comparison to untreated hypertensive rats. Both doses of sEH inhibitors significantly reduced (*** p < 0.001) high blood pressure-induced decrease in developed tension in comparison to untreated hypertensive rats. (C) Diabetes significantly decreased (b p < 0.01) developed tension after IR in comparison to normal rats treated with water, and treatment with metformin and both sEH inhibitors significantly reduced (** p < 0.01) diabetes driven decrease in developed tension in comparison to untreated diabetic rats. Metformin (500 mg/kg) was more effective (* p < 0.05) than t-TUCB (0.1 mg/kg). Data are presented as mean ± SEM of 5–6 observations. One-way ANOVA followed by Tukey’s multiple comparison test was used for statistical calculation.