. Author manuscript; available in PMC: 2018 Nov 1.

Published in final edited form as: Clin Pharmacokinet. 2017 Nov;56(11):1343–1353. doi: 10.1007/s40262-017-0525-5

Table 1.

Physico-chemical, ADME, and Anatomic/Physiologic Data for clindamycin phosphate and clindamycin^a

	Clindamycin phosphate	Clindamycin
Physico-chemical^b
LogP	0.95	2.16
pKa	Base 6.78	Base 7.55
MW, g/mol	504.963	424.98
Solubility at pH7, mg/L	3220	30.6
ADME
fu_p	0.22	0.06 (22-24, 27)
Binding protein^c	α1-acid glycoprotein	α1-acid glycoprotein (22-24, 27)
CL_{int(plasma-ALP)}	0.8 L/min
CL_{int(hep-CYP3A4)}	-	2.21 ul/min/pmol P450
CL_{int(hep-CYP3A5)}	-	0.28 ul/min/pmol P450
Tubular secretion	-	0.1038 L/min
Renal filtration	0.044	1

LogP, logarithm of the octanol-water partition coefficient (lipophilicity); pka, negative logarithm of the acid dissociation constant; MW, molecular weight; ADME, absorption distribution metabolism elimination; fu_p, plasma fraction unbound; CL _{int(plasma-ALP)}, intrinsic clearance of plasma alkaline phosphatase; CL _{int(hep-CYP3A4)}, intrinsic clearance of hepatic isozyme CYP3A4; CL _{int(hep-CYP3A5)}, intrinsic clearance of hepatic isozyme CYP3A5.

All physicochemical data came from DrugBank (18).

We assumed the same degree of protein binding to α1-acid glycoprotein for clindamycin phosphate and clindamycin.