Table 1.
Histological findings in 30 explanted livers of primary sclerosing cholangitis patients with biliary low-grade dysplasia or high-grade dysplasia/cholangiocarcinoma
| LGD | HGD + CCA2 | P value | |
| n | 16 | 14 | |
| Early LT1, n | 12 | 11 | 1.000 |
| Histology intrahepatic | |||
| Liver weight, g (IQR) | 1380 (1190-1717) | 1408 (1262-1487) | 0.910 |
| Fibrosis stage 1-4 (IQR) | 3.5 (3.0-4.0) | 3.0 (2.0-4.0) | 0.473 |
| Stage 1-2, n | 3 | 4 | 0.675 |
| Stage 3-4, n | 13 | 10 | 0.675 |
| Histology extrahepatic, n | |||
| Purulent cholangitis | 12 | 6 | 0.142 |
| Ulceration | 11 | 6 | 0.224 |
| Intestinal metaplasia | 2 | 1 | 0.822 |
| Squamous metaplasia | 1 | 0 | 0.790 |
1
In early LTs, suspicion of biliary neoplasia was an important decision criterion for LT;
2
CCA four patients; HGD ten patients. Values are median values unless otherwise indicated (IQR). P values: Mann-Whitney U-test for continuous variables, Fisher's exact test for dichotomous variables. CCA: Cholangiocarcinoma; HGD: High-grade dysplasia; IQR: Interquartile range; LGD: Low-grade dysplasia; LT: Liver transplantation.