Figure 8. Knockdown and constitutive activation perturbation simulations reveal key regulatory nodes in glutamate + CD40L-induced c-Myc activation.

Each node in the network was systematically, individually forced permanently into an “off” state, knocked down (KD), or an “on” state, constitutively activated (CA), during the combination treatment scenario. Results from these simulations were then compared with the unperturbed combination treatment scenario, and changes in c-Myc/MAX activity are shown. NOX, Nitrogen oxides; Tpl2, tumor progression locus 2; PTP1b, protein tyrosine phosphatase 1b.