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. 2017 Jul 27;102(4):1093–1102. doi: 10.1189/jlb.1A0417-147RR

Figure 4. LRRK2 G2019S mutation promotes generation of suppressive myeloid cells in vitro.

Figure 4.

(A) Rat bone marrow cells were differentiated with mM-CSF (20 ng/ml) for 7 d, and examined for RP-1 and HIS48. (B) T cell proliferation-suppression activity of myeloid cells was examined. Myeloid cells prepared as in (A) with M-CSF (20 ng/ml) for 7 d and then activated with LPS (1 μg/ml) for 24 h before coculture with isolated rat CD4+ T cells in the presence of SEB (5 μg/ml) for 3 d. Representative dot plots and pooled data (n = 3) are shown. *Significant differences (P ≤ 0.05) from control groups. Error bars indicate means ± sem.