Figure 7. LRRK2 G2019S gene affects bone marrow myelopoiesis and peripheral myeloid cell differentiation and function.

The LRRK2 G2019S gene decreases the numbers of myeloid progenitors in the bone marrow of transgenic rats but abnormally increases peripheral expansion of suppressive myeloid cells, which suppress Th17 cell differentiation. Because myeloid cells and Th17 cells have central roles in promoting immunity and mediating inflammatory responses, the LRRK2 G2019S–induced dysregulation is likely to have significant effects on the inflammatory responses in various tissues.