Fig. 2. Ca2+-activated potassium channels mediate afterhyperpolarization. Ca2+-activated potassium channels such as BKCa and SKCa channels mediates afterhyperpolarization. BKCa channels are directly activated by Ca2+ binding where SKCa channels are activated by Ca2+-calmodulin. They are functionally linked to various voltage-gated Ca2+ channels depending on neuronal types.
