Fig. 1. NADPH oxidase (NOX) activation. NOX comprises cytosolic (p47phox, p67 phox, p40 phox and Rac) and membrane subunits (gp91 phox and p22 phox). During activation of NOX, cytosolic subunits comprise a multi-component enzyme and migrate to the plasma membrane to dock with the membrane subunits. This multisubunit enzyme produces a superoxide anion (O2•–).
