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. 2017 Sep 13;7:11501. doi: 10.1038/s41598-017-11914-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overexpression of SEMA3C causes an upregulation of EMT markers. Expression levels of a panel of EMT markers were compared between SEMA3C-overexpressing RWPE-1 cells (RWPE-1-SEMA3C) and control cells (RWPE-1-FUGWBW). Significant upregulation of N-cadherin, ZEB2, ZEB1, fibronectin, vimentin, and downregulation of E-cadherin was observed in RWPE-1-SEMA3C compared to control RWPE-1-FUGWBW as shown by qPCR. (a) Data represent mean, ± SD; ***p < 0.001 comparing RWPE-1-SEMA3C to RWPE-1-FUGWBW cells. These findings were verified by Western blot analysis; (b) Western blot band intensity was quantitated by densitometry (b, right); ‘F’ = FUGWBW, ‘S’ = SEMA3C.