Table 1.
Systolic blood pressure (SBP), albuminuria (ALB), 24-h urine volume (V), urinary osmolality (U), glomerular filtration rate (GFR), and fractional excretions of sodium (FENa+) and potassium (FEK+) in 60-day-old pups from the control and losartan-treated groups.
| Groups | ||||
|---|---|---|---|---|
| control | control + calcitriol | losartan | losartan + calcitriol | |
| SBP (mmHg) | 120 ± 1.3 | 117 ± 1.4 | 140 ± 0.8***,### | 129 ± 0.7***,###,§§§ |
| ALB (mg 24 h−1) | 0.5 (0.4; 0.6) | 0.4 (0.4; 0.6) | 7.9 (6.8; 9.6)***,### | 4.9 (4.2; 5.6)**,###,§§§ |
| V (ml) | 14.5 ± 0.79 | 13.88 ± 1.66 | 35.9 ± 3.21***,### | 33.6 ± 3.23***,### |
| U (mOsm kg H20−1) | 1.578 ± 75 | 1.612 ± 121 | 703 ± 25***,### | 791 ± 32***,### |
| GFR (ml min−1100 g−1) | 0.88 ± 0.07 | 0.89 ± 0.04 | 0.56 ± 0.12*,# | 0.77 ± 0.16*,#,§ |
| FENa+ (%) | 0.15 (0.1; 0.3) | 0.14 (0.1; 0.3) | 0.55 (0.3; 0.8)**,## | 0.43 (0.4; 0.9)*,#,§ |
| FEK+ (%) | 27.2 (21.3; 36.1) | 24.3 (28.3; 58.7) | 88.1 (44.9; 114.4)*,# | 69.4 (36.8; 105.1)*,#,§ |
Data are expressed as median and interquartile range (25th–75th) (ALB, FE) or mean ± SEM (SBP, V, U, GFR). n = 7–12 animals per group. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. control; # P < 0.05, ## P < 0.01 and ### P < 0.001 vs control + calcitriol; and § P < 0.05, and §§§ P < 0.001 vs. losartan.