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. 2017 Sep 13;7:11490. doi: 10.1038/s41598-017-09734-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of the 106 ribose-methylated residues on 3-D models of human ribosomal subunits. (A) Entire ribosome: solvent view. The models of the subunits are based on PDB entry 4UG0⁴⁷. The four rRNAs are shown as ribbons (18S, dark grey; 28S, light gray; 5S, red; 5.8S, purple) with the modifications as spheres. The color code used for the modifications is described in panels B and C. SSU, small subunit; LSU, large subunit. (B) Small subunit (40S): interface view. Left, 18S rRNA shown as a dark grey ribbon with the modifications as spheres. Right, simplified view showing only the modifications and the E-site tRNA for orientation. The decoding site (DCS) is highlighted in black. Small ribosomal subunit morphological features are indicated: Bk, beak; H, head; Sh, shoulder; Bd, body; Lf, left foot; Rf, right foot; and h45, helix 45. Each modification is color-coded according to the categories identified in this work. (C) Large subunit (60S): interface view. Legend as in panel B. The peptidyl transferase center (PTC) residues are highlighted in black. Two PTC residues are 2′-O-methylated (shown in grey). CP, central protuberance.