Fig. 4. VitabridC12 inhibited imiquimod-induced inflammatory responses in the mouse skin. Total RNA was isolated from the skin lesions of imiquimod-induced mice, and quantitative real-time polymerase chain reaction was performed to examine psoriasis-specific cytokines. VitabridC12 decreased the mRNA expression levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, IL-17A, IL-22, CXCL1, CCL20, and CCL17, and thereby ameliorated imiquimod-induced psoriasiform inflammation in the skin lesion. Data represent mean values±standard error (n=5). *p<0.05. The data shown are representative of three independent experiments.
