Fig. 1.

Schematic representation of cardiomyocyte structure and relevant cellular and molecular components that are mutated in cardiac diseases. This schematic shows the cardiac proteins encoded by mutated genes for which hiPSCs have been generated and reviewed here. Disease genes of interest, which are also listed in Table 3, are located in different compartments of the cardiomyocyte, such as the extracellular matrix, sarcoplasmic reticulum (SR), cytoskeleton, sarcomere, desmosome, lysosome, mitochondrion, and the nucleus