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. 2015 May 12;2:1–14. doi: 10.1016/j.plabm.2015.04.001

Fig. 1.

Fig. 1

Relationship between doses of vitamin D3 supplementation and net changes in serum 25OHD concentrations in RCTs by assay type. Legends: Each empty circle represents one study. The area of the circle is proportional to the inverse of the within-study variances. The larger the bubble is, the larger the sample size and the smaller the standard error of the changes in 25OHD.

Reprinted with permission from Newberry et al. [8].