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Schematic of KSHV-promoted activation of STAT3, PI3 K/Akt, MAPK and PLCγ/NFAT pathways contributing to proliferation and migration of KSHV-infected endothelial cells. The transmembrane viral proteins vGPCR, K1 and K15 as well as the viral IL6 homologue vIL6, kaposin B and ORF36 activate PLCγ, Akt, MAPK and STAT3 pathways. Some of these could be promising targets to inhibit the development of Kaposi's sarcoma.
