Table 1.
LTR element | cellular gene | effect | cancer type | study |
---|---|---|---|---|
MaLR-THE1B | CSF1R | overexpression | Hodgkin's lymphoma | [63] |
LTR16B2 | ALK | truncation | melanoma | [64] |
MaRL- MLT1H2 | ERBB4 | truncation | ALK-negative anaplastic large-cell lymphoma | [65] |
HERV-E | CD5 | alternative splicing with loss of function | healthy B cells and chronic lymphocytic leukaemia cells | [66] |
HERV-H | GSDML | overexpression | healthy tissues and cancer cell lines | [67] |
HERV-L33 HERV-H |
DNAJC15 | ectopic expression | cancer cell lines | [68] |
HERV-P | NAIP | not tested | healthy tissue (testis-specific) | [69] |
HERV-E | FABP7 | overexpression | DLBCL (diffuse large B-cell lymphoma) | [70] |
LOR1a | IRF5 | overexpression | Hodgkin's lymphoma | [71] |
ERV9 | CADM2 | alternative splicing | stem cells and erythroleukaemia cell line | [72,73] |
ERV9 | SEMA3A | alternative splicing | stem cells and erythroleukaemia cell line | [72,73] |
ERV9 | TNFRSF10B | restored expression | healthy tissue (testis-specific) | [74] |
ERV9 | TP63 | restored expression | healthy tissue (testis-specific) | [75] |
MER41 | AIM2 | interferon inducibility | healthy cells | [76] |