Table 4.
Serious games with cognitive training (n=4).
| Author, year | Study type | Intervention type | Technology type | Populationa | Outcomes | OCEBM levelb | Effective/Results |
| Finn and McDonald, 2011 [36] | RCT | Serious games, cognitive training | Computer | 25 pts w/ MCI; age: mean 74.2 years; MMSE: mean 27.8 | Cognition, Mood, Anxiety, Stress | 2 | No, only improvement was in visual sustained attention; no improvement in cognition, depression, or anxiety |
| Hsiung et al, 2009 [40] | Pilot | Serious games, cognitive training | Handheld device | 17 pts total 12 w/ MCI, 2 healthy, 3 w/ subjective memory complaints; age: mean 72 years: MMSE: mean NR | Cognition | 4 | No improvement in cognition |
| Manera et al, 2015 [41] | Pilot | Serious games, cognitive training | Tablet | 9 pts w/ MCI, 12 pts w/ Alzheimer disease; age mean 78.4 years; MMSE MCI: mean 27.2, MMSE Alzheimer disease: mean 18.4 | Cognition | 4 | Yes, improvement in praxis & executive function |
| Merilampi et al, 2014 [42] | Pilot | Serious games, cognitive training | Tablet, computer | 16 pts w/ mild-to-moderate cognitive impairment; age: mean 90 years; MMSE: mean 21.6 | Cognition | 4 | No improvement in cognition |
aMCI: mild cognitive impairment; MMSE: Mini-Mental State Examination; NR: not reported.
bOxford Centre for Evidence-based Medicine’s Levels of Evidence and Grades of Recommendation (1=highest quality; 5=lowest quality).